一、基本信息
姓名：郝杨
职称：讲师
所在部门：实验动物系
研究方向：人类疾病模型、动物遗传育种与繁殖
电子邮件：yhao@jlu.edu.cn
办公室：吉林大学和平校区实验动物中心202
二、学习与工作经历
2011.09 – 2015.06 吉林大学动物科学学院，实验动物 理学学士
2015.09 – 2018.06 吉林大学动物科学学院，动物学 理学硕士
2018.12 – 2023.01 荷兰莱顿大学医学中心，基础医学 博士
2023.03 – 2025.03 吉林大学，教育部国际交流计划引进项目 博士后
2023.03 – 2026.03 吉林大学，教育部海外博士后引才专项 博士后
2026.06 – 至今 吉林大学，动物科学学院 讲师
三、主要教学工作
暂无。
四、科研项目
主要研究方向聚焦动物配子、胚胎发育机制，以及胚胎工程和繁殖调控技术开发研究，为解决家畜繁殖障碍提供了新的策略和科学参考。同时关注癌症个性化免疫治疗、关键遗传事件挖掘及精准诊疗靶标的筛选相关领域。
1. 中国博士后科学基金面上资助项目，8万元，2024.07 - 2026.07，主持
2. 国家自然科学基金青年科学基金C类，30万，2026.01-2028.12，主持
3. 吉林大学新聘教师科研启动经费目，5万元，2026.06 - 2028.06，主持
4. 吉林大学“强农兴农行动计划”优秀青年教师培育项目，6万元，2026.06 - 2027.12，主持
五、科研成果
1. Liu, Y., Mu, J., Yu, J., Li, Q., Li, T., Feng, Q., Sun, T., Sun, K., Hao, Y.# (通讯), Yu, J.#, & Wang, D.# (2026). RNA binding motif protein RBM41 promotes colorectal tumorigenesis by impeding the maturation of NDRG1 pre-mRNA. Cell death discovery, 12(1), 276. (中科院1区，IF=10.4)
2. Jin, M. *, Ji, Z. *, Zhou, H. *, Li, Y., Wei, J., Zhen, Y., Sun, L., Hao, Y.#(通讯), & Wang, D.# (2026). Naringenin alleviates LPS-induced mastitis by inhibiting inflammation and regulating gut microbiota, Animals and Zoonoses, doi.org/10.1016/j.azn.2026.03.002. (中国科技卓越期刊)
3. Hao, Y.* (一作), Qian, Y.*, Liu, D., Li, F., Zhou, H., Jin, M., Li, C., Liu, T.#, & Wang, D.# (2026). Biological applications and future perspectives for bioactive compounds as pig feed additives. Animal nutrition. 26, 354-379. (中科院1区Top，IF=8.3)
4. Feng, Q.*, Hao, Y.* (共一), Cheng, Y., Liu, D., Jin, M., Li, T., Li, C., Li, Q., Sun, L., Gao, Y., Mu, J., Ji, F., Liu, X.#, & Wang, D.# (2026). CAMK1 Suppresses Anoikis Resistance and Liver Metastasis in Colorectal Cancer. FASEB journal, 40(10). (中科院2区，IF=4.3)
5. Zhou, H. Z.*, Wang, D. X.*, Qian, Y. Q., Wei, J. Q., Ma, S., Feng, Y. J., & Hao, Y# (通讯). (2025). Large animal models for investigating the applications of photodynamic therapy. Zoological research, 46(3), 551–575. (中科院1区Top，IF=5.6)
6. Hao, Y. (一作), Ma, S., Gu, Z., Haghparast, A., Schomann, T., Yu, Z., He, Y., Dong, X., Cruz, L. J.#, & Ten Dijke, P.# (2023). Combination of photodynamic therapy and stimulator of interferon genes (STING) agonist inhibits colorectal tumor growth and recurrence. Cancer communications. 43(4):513-518. (中科院1区Top，IF=28.4)
7. Hao, Y. (一作), Ji, Z., Zhou, H., Wu, D., Gu, Z., Wang, D.#, & Ten Dijke, P#. (2023). Lipid-based nanoparticles as drug delivery systems for cancer immunotherapy. MedComm, 4(4), e339. (中科院1区Top，IF=14.1)
8. Hao, Y. (一作), Chung, C. K., Gu, Z., Schomann, T., Dong, X., Veld, R. V. H. I., Camps, M. G. M., Ten Dijke, P., Ossendorp, F. A.#, & Cruz, L. J.# (2022). Combinatorial therapeutic approaches of photodynamic therapy and immune checkpoint blockade for colon cancer treatment. Molecular biomedicine. 3(1):26 (中科院2区，IF=13)
9. Hao, Y. (一作), Gu, Z., Yu, Z., Schomann, T., Sayedipour, S., Aguilar, J. C., Ten Dijke, P.#, & Cruz, L. J.# (2022). Photodynamic Therapy in Combination with the Hepatitis B Core virus-like particles (HBc VLPs) to Prime Anticancer Immunity for Colorectal Cancer Treatment. Cancers. 14(11):2724. (中科院2区，IF=5.2)
10. Hao, Y. (一作), Chung, C. K., Yu, Z., Huis In 't Veld, R. V., Ossendorp, F. A., Ten Dijke, P.#, & Cruz, L. J.# (2022). Combinatorial Therapeutic Approaches with Nanomaterial-Based Photodynamic Cancer Therapy. Pharmaceutics,14(1), 120. (中科院2区，IF=6.9)
11. Hao, Y. (一作), Baker, D., & Ten Dijke, P. (2019). TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis. International journal of molecular sciences, 20(11), 2767. (中科院2区，IF=5.6，ESI高被引 1392次)
12. Hao, Y.* (一作), Wang, G.*, Lin, C.*, Li, D., Ji, Z., Gao, F., Li, Z., Liu, D., & Wang, D.# (2017). Valproic Acid Induces Decreased Expression of H19 Promoting Cell Apoptosis in A549 Cells. DNA and cell biology, 36(6), 428–435. (中科院3区, IF=2.6)
13. Wang, D.*, Wang, G.*, Yang, H.* (共一), Liu, H., Li, C., Li, X., Lin, C., Song, Y., Li, Z.#, & Liu, D.# (2017). DNA methylation modulates H19 and IGF2 expression in porcine female eye. Genetics and molecular biology, 40(1), 153–159. (中科院4区, IF=2.1)
14. Wang, D. *, Liu, Z. *, Yao, H. *, Hao, Y. * (共一), Zhou, L., Du, J., Zhu, Y., Xu, Y., Wang, G., Song, Y., & Li, Z. (2017). Disruption of NNAT, NAP1L5 and MKRN3 DNA methylation and transcription in rabbit parthenogenetic fetuses. Gene, 626, 158–162. (中科院3区, IF=3.8)
15. Hao, J. *, Li, C. *, Lin, C. *, Hao, Y. *(共一), Yu, X., Xia, Y., Gao, F., Jiang, Z., & Wang, D. (2020). Targeted point mutations of the m6A modification in miR675 using RNA-guided base editing induce cell apoptosis. Bioscience reports, 40(5), BSR20192933. (中科院2区, IF=4.7)
16. Qian, Y., Hui, F., Niu, W., Wang, D., Hao, Y., Meng, Q., Ren, S., Kong, D., Gong, H., Wu, J., Chen, K., Alariqi, M., Gao, J., Li, Z., & Jin, S. (2025). Double-stranded DNA deaminase DddAE1347A can increase the efficiency and targeting range of cytidine base editors. Genome biology, 26(1), 391. (中科院1区TOP，IF=9.2)
17. Li, T., Yin, J., Hao, Y., Gao, W., Li, Q., Feng, Q., Tao, B., Hao, M., Liu, Y., Lin, C., & Wang, D. (2025). Single-cell sequencing and organoids: applications in organ development and disease. Molecular biomedicine, 6(1), 134. (中科院2区，IF=13)
18. Ma, S., Huis In't Veld, R. V., Hao, Y., Gu, Z., Rich, C., Gelmi, M. C., Mulder, A. A., van Veelen, P. A., Vu, T. K. H., van Hall, T., Ossendorp, F. A., & Jager, M. J. (2024). Tumor Pigmentation Does Not Affect Light-Activated Belzupacap Sarotalocan Treatment but Influences Macrophage Polarization in a Murine Melanoma Model. Investigative ophthalmology & visual science, 65(1), 42. (中科院2区，IF=5.5)
19. Huang, H., Fu, J., Peng, H., He, Y., Chang, A., Zhang, H., Hao, Y., Xu, X., Li, S., Zhao, J., Ni, J., & Dong, X. (2024). Co-delivery of polyphyllin II and IR780 PLGA nanoparticles induced pyroptosis combined with photothermal to enhance hepatocellular carcinoma immunotherapy. Journal of nanobiotechnology, 22(1), 647. (中科院1区Top，IF=15)
20. Gu, Z., Hao, Y., Schomann, T., Ossendorp, F., Ten Dijke, P., & Cruz, L. J. (2023). Enhancing anti-tumor immunity through liposomal oxaliplatin and localized immunotherapy via STING activation. Journal of controlled release, 357, 531–544. (中科院1区Top，IF=12.4)
21. Gu, Z., Da Silva, C. G., Hao, Y., Schomann, T., Camps, M. G. M., van der Maaden, K., Liu, Q., Ossendorp, F., & Cruz, L. J. (2023). Effective combination of liposome-targeted chemotherapy and PD-L1 blockade of murine colon cancer. Journal of controlled release, 353, 490–506. (中科院1区Top，IF=12.4)
22. Dong, X., Zeng, Y., Zhang, Z., Fu, J., You, L., He, Y., Hao, Y., Gu, Z., Yu, Z., Qu, C., Yin, X., Ni, J., & Cruz, L. J. (2021). Hypericin-mediated photodynamic therapy for the treatment of cancer: a review. The Journal of pharmacy and pharmacology, 73(4), 425–436. (中科院3区，IF=3.7)
23. Shen, Z., Ma, Y., Ji, Z., Hao, Y., Yan, X., Zhong, Y., Tang, X., & Ren, W. (2018). Arachidonic acid induces macrophage cell cycle arrest through the JNK signaling pathway. Lipids in health and disease, 17(1), 26. (中科院2区，IF=6.9)
六、获得荣誉
1. 2022年，广东省博士后创新创业大赛之科技海归领航赛，银奖（4/4）
2. 2023年，吉林省第二届博士后创新创业大赛，银奖（3/3）
3. 2023年，全国博士后创新创业大赛创业组，三等奖（3/8）
4. 2023年，全国博士后创新创业大赛创业组，优秀博士后
5. 2024年，吉林大学动物科学学院学术年会一等奖
6. 2025年，吉林大学动物科学学院学术年会一等奖
7. 2025年，吉林大学动物科学学院伯乐进步奖及三等奖
