一、基本信息

姓名：郑毅

职称：讲师

所在部门：动物科学系

研究方向：动物遗传育种与繁殖

办公电话：15500042557

电子邮件：zhengyi@jlu.edu.cn

二、学习与工作经历

2014.09-2018.06，吉林大学，动物科学学院，动物科学专业，农学学士

2018.09-2020.06，吉林大学，动物科学学院，动物遗传育种与繁殖专业，农学硕士

2020.09-2023.06，吉林大学，动物科学学院，畜牧学，农学博士

2023.09-至今，吉林大学，动物科学学院，讲师

三、主要教学工作 

本科生课程：《动物繁殖学》

四、主要科研工作（包括科研项目）

主要研究领域为松果体褪黑素合成作用机制与动物繁殖激素调控。熟悉基因的作用机制和研究手段、精通细胞培养及药物作用机制研究。研究方向主要包括基于多组学技术，挖掘与解析影响垂体激素合成分泌与调控作用的分子机制。参与国家自然科学基金《ciRS-187作为miR-187分子海绵通过BMP-Smad1/5/8信号通路调控牛卵丘细胞增殖与凋亡的分子机制》和国家自然科学基金《circAkap17b通过MAPK信号通路调控牛腺垂体FSH分泌机制研究》。

五、科研成果（著作、专利、论文）

1.Zheng Y#, Wang HQ#, Guo HX, Xie HL, Zhang WD, Han DX, Jiang H, Yuan B, Zhang JB. CircRNA-WNK2 Acts as a ceRNA for miR-328a-3p to Promote AANAT Expression in the Male Rat Pineal Gland. Endocrinology. 2022 Feb 1;163(2):bqab255. doi: 10.1210/endocr/bqab255. PMID: 34918065.

2.Zheng Y#, Zhou Y#, Huang Y, Wang H, Guo H, Yuan B, Zhang J. Transcriptome sequencing of black and white hair follicles in the giant panda. Integr Zool. 2023 May;18(3):552-568. doi: 10.1111/1749-4877.12652. Epub 2022 May 30. PMID: 35500067.

3.Guo HX#, Zheng Y#, Zhao GK, Wang HQ, Yu S, Gao F, Zhang JB, Zhang YH, Yuan B. Circ-ERC2 Is Involved in Melatonin Synthesis by Regulating the miR-125a-5p/MAT2A Axis. Int J Mol Sci. 2022 Dec 7;23(24):15477. doi: 10.3390/ijms232415477. PMID: 36555116; PMCID: PMC9778726.

4.Zhao GK#, Zheng Y#, Guo HX, Wang HQ, Ji ZH, Wang T, Yu S, Zhang JB, Yuan B, Ren WZ. TRH Regulates the Synthesis and Secretion of Prolactin in Rats with Adenohypophysis through the Differential Expression of miR-126a-5p. Int J Mol Sci. 2022 Dec 14;23(24):15914. doi: 10.3390/ijms232415914. PMID: 36555554; PMCID: PMC9781503.

5.Zheng Y#, Jiang H#, Wang HQ, Guo HX, Han DX, Huang YJ, Gao Y, Yuan B, Zhang JB. Identifying daily changes in circRNAs and circRNA-associated-ceRNA networks in the rat pineal gland. Int J Med Sci. 2021 Jan 14;18(5):1225-1239. doi: 10.7150/ijms.51743. PMID: 33526984; PMCID: PMC7847611.

6.Lyu CC, Yuan B, Che HY, Meng Y, Zheng Y, He YT, Ji ZH, Cong S, Ji XY, Jiang H, Zhang JB. RNA binding protein Musashi2 regulates dairy cows' mastitis by activating the TGFβ signaling pathway. Int J Biol Macromol. 2023 Jun 12:125331. doi: 10.1016/j.ijbiomac.2023.125331. Epub ahead of print. PMID: 37315671.

7.Wang T, Zhao G, Yu S, Zheng Y, Guo H, Wang H, Zhao P, Xie W, Ren W, Yuan B. Sequencing of the Pituitary Transcriptome after GnRH Treatment Uncovers the Involvement of lncRNA-m23b/miR-23b-3p/CAMK2D in FSH Synthesis and Secretion. Genes (Basel). 2023 Mar 31;14(4):846. doi: 10.3390/genes14040846. PMID: 37107604; PMCID: PMC10137480.

8.Liu JB, Zhang JB, Yan XM, Xie PG, Fu Y, Fu XH, Sun XL, Han DX, Li SP, Zheng Y, Gao Y, Kim NH, Yuan B, Jiang H. DNA Double-Strand Break-Related Competitive Endogenous RNA Network of Noncoding RNA in Bovine Cumulus Cells. Genes (Basel). 2023 Jan 22;14(2):290. doi: 10.3390/genes14020290. PMID: 36833217; PMCID: PMC9956238.

9.Zhang YH, Xie HL, Yang YW, Wen J, Liu RR, Zhao GP, Tan XD, Liu Z, Zheng Y, Zhang JB. miR-375 upregulates lipid metabolism and inhibits cell proliferation involved in chicken fatty liver formation and inheritance via targeting recombination signal binding protein for immunoglobulin kappa J region (RBPJ). Poult Sci. 2023 Jan;102(1):102218. doi: 10.1016/j.psj.2022.102218. Epub 2022 Oct 14. PMID: 36410068; PMCID: PMC9678763.

10.Zhang W, Ren W, Han D, Zhao G, Wang H, Guo H, Zheng Y, Ji Z, Gao W, Yuan B. LncRNA-m18as1 competitively binds with miR-18a-5p to regulate follicle-stimulating hormone secretion through the Smad2/3 pathway in rat primary pituitary cells. J Zhejiang Univ Sci B. 2022 Jun 15;23(6):502-514. doi: 10.1631/jzus.B2101052. PMID: 35686528; PMCID: PMC9198230.

11.Xie HL, Zhang YH, Tan XD, Zheng Y, Ni HY, Dong LP, Zheng JL, Diao JZ, Yin YJ, Zhang JB, Sun XQ, Yang YW. miR-375 Induced the Formation and Transgenerational Inheritance of Fatty Liver in Poultry by Targeting MAP3K1. DNA Cell Biol. 2022 Jun;41(6):590-599. doi: 10.1089/dna.2022.0078. Epub 2022 May 9. PMID: 35533015.

12.Wang HQ, Zhang JB, Zheng Y, Zhang WD, Guo HX, Cong S, Ding Y, Yuan B. Comprehensive analysis of differences in N6-methyladenosine RNA methylomes in the rat adenohypophysis after GnRH treatment. FASEB J. 2022 Mar;36(3):e22204. doi: 10.1096/fj.202101608R. PMID: 35147984.

13.Guo HX, Yuan B, Su MT, Zheng Y, Zhang JY, Han DX, Wang HQ, Huang YJ, Jiang H, Zhang JB. Identification of Circular RNAs in the Anterior Pituitary in Rats Treated with GnRH. Animals (Basel). 2021 Aug 31;11(9):2557. doi: 10.3390/ani11092557. PMID: 34573523; PMCID: PMC8466137.

14.Huang YJ, Gao Y, Wang CJ, Han DX, Zheng Y, Wang WH, Jiang H, Yuan B, Zhang JB. Hydroxyurea regulates the development and survival of B16 Melanoma Cells by upregulating MiR-7013-3p. Int J Med Sci. 2021 Mar 3;18(8):1877-1885. doi: 10.7150/ijms.52177. PMID: 33746605; PMCID: PMC7976580.

15.Wang CJ, Gao F, Huang YJ, Han DX, Zheng Y, Wang WH, Jiang H, Gao Y, Yuan B, Zhang JB. circAkap17b acts as a miR-7 family molecular sponge to regulate FSH secretion in rat pituitary cells. J Mol Endocrinol. 2020 Nov;65(4):135-148. doi: 10.1530/JME-20-0036. PMID: 33048061.

16.Zhang Z, Meng Y, Gao F, Xiao Y, Zheng Y, Wang HQ, Gao Y, Jiang H, Yuan B, Zhang JB. TGF-β1-Mediated FDNCR1 Regulates Porcine Preadipocyte Differentiation via the TGF-β Signaling Pathway. Animals (Basel). 2020 Aug 11;10(8):1399. doi: 10.3390/ani10081399. PMID: 32796679; PMCID: PMC7459525.

17.Han DX, Sun XL, Wang CJ, Yu ZW, Zheng Y, Huang YJ, Wang WH, Jiang H, Gao Y, Yuan B, Zhang JB. Differentially expressed lncRNA-m433s1 regulates FSH secretion by functioning as a miRNA sponge in male rat anterior pituitary cells†. Biol Reprod. 2019 Aug 1;101(2):416-425. doi: 10.1093/biolre/ioz100. PMID: 31201415.

18.Wang CJ, Guo HX, Han DX, Yu ZW, Zheng Y, Jiang H, Gao Y, Yuan B, Zhang JB. Pituitary tissue-specific miR-7a-5p regulates FSH expression in rat anterior adenohypophyseal cells. PeerJ. 2019 Apr 9;7:e6458. doi: 10.7717/peerj.6458. PMID: 30993031; PMCID: PMC6461031.

19.于淞#,郑毅#,郭海祥等.吉林省肉牛良种扩繁技术与瓶颈[J].吉林农业大学学报,2023,45(04):391-395.DOI:10.13327/j.jjlau.2023.20303.

20.郑毅,王皓琪,于淞等.褪黑激素在羊生产中的应用[J].黑龙江动物繁殖,2023,31(02):19-24.DOI:10.19848/j.cnki.ISSN1005-2739.2023.01.0002.

21.王皓琪,郑毅,马一然等.激活素A调控促卵泡素合成与分泌的研究进展[J].黑龙江动物繁殖,2023,31(01):32-37.DOI:10.19848/j.cnki.ISSN1005-2739.2022.11.0010.

22.郑毅,袁宝,姜昊等.哺乳动物松果体非编码RNA研究进展[J].内蒙古民族大学学报(自然科学版),2020,35(06):509-515.DOI:10.14045/j.cnki.15-1220.2020.06.009.

23.高妍,郑毅,官员.猪胚胎冷冻技术的研究历程与未来展望[J].中国猪业,2020,15(02):40-44+50.DOI:10.16174/j.cnki.115435.2020.02.007.

24.郑毅,唐鸿宇,李天宇等.青贮饲料有氧稳定性测定装置的设计与验证[J].草地学报,2018,26(01):238-243.

25.李天宇#,郑毅#,解盼盼等.7种菌糠及其青贮饲料的营养价值和发酵品质[J].中国畜牧杂志,2018,54(01):94-98.DOI:10.19556/j.0258-7033.2018-01-094.