一基本信息
姓 名:徐媛媛
职 称:副教授
所在部门:生物技术系
研究方向:基因修饰动物
办公电话:0431-87836176
电子邮件:xuyuan@jlu.edu.cn
二学习与工作经历:
2003-2008年,吉林大学药学院生物工程专业理学学士
2008-2010年,吉林大学药学院生物医学工程专业医学硕士
2010-2016年,吉林大学基础医学院生物化学与分子生物学专业理学博士
2016-至今,吉林大学动物科学学院生物技术系讲师
三主要教学工作(承担的课程)
本科生课程:生物化学,生物制药与发酵工程综合实验
四主要科研工作(包括科研项目)及近三年科研成果
1.博士后面上项目二等资助,2018M631879,PAX4基因过表达模型兔的构建及糖尿病相关机制研究,5万元,主持
2.Yuanyuan Xu(#), Yong Wang(#), Yuning Song, Jichao Deng, Mao Chen, Hongsheng Ouyang, Liangxue Lai(*), Zhanjun Li(*). Generation and phenotype identification of PAX4 gene knockout rabbit by CRISPR/Cas9 system, G3, 2018.6.27.
3.Yuning Song(#), Yuanyuan Xu(#), Mingming Liang, Yuxin Zhang, Mao Chen, Jichao Deng; Zhanjun Li(*). CRISPR/Cas9-Mediated Mosaic Mutation of SRY Gene Induces Hermaphroditism in Rabbits, Bioscience Reports, 2018.3.21, 38(2).
4.Mao Chen(#), Bing Yao(#), Qiangbing Yang(#), Jichao Deng, Yuning Song, Tingting Sui, Lina Zhou,HaoBing Yao, Yuanyuan Xu, Hongsheng Ouyang, Daxin Pang, Zhanjun Li(*), Liangxue Lai(*). Truncated C-terminus of fibrillin-1 induces Marfanoid-progeroidlipodystrophy (MPL) syndrome in rabbit, Dis Model Mech, 2018.3.5,11(4).
5.Sui Tingting(#), Liu Di(#), Liu Tingjun, Deng Jichao, Chen Mao, Xu Yuanyuan, Song Yuning, Ouyang Hongsheng, Lai Liangxue(*), Li Zhanjun(*). LMNA-mutated Rabbits: A Model of Premature Aging Syndrome with Muscular Dystrophy and Dilated Cardiomyopathy, Aging and Disease, 2018.2.16, 9(6).
6.Huan Liu(#), Tingting Sui(#), Di Liu, Tingjun Liu, Mao Chen, Jichao Deng, Yuanyuan Xu(*), Zhanjun Li(*). Multiple homologous genes knockout (KO) by CRISPR/Cas9 system in rabbit, Gene, 2018.1.12, 647:261-267.
7.Yuanyuan Xu(#), Jialin Liu, Li Hua, Yue Xiao, Yaping Tian, Sheng Guo, Xiaoling Zhang, Chunyan He, Liying Wang(*), Yongli Yu(*). An immune regulatory CCT repeat containing oligodeoxynucleotide capable of causing hair loss in male mice, Human and Experimental Toxicology, 2016, 35 (11):1161-1172.