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郝林琳

发布日期:2016-06-23 作者: 点击:


一基本信息:

姓名:郝林琳

职称:教授

博士生导师

所在部门:生物技术系

研究方向:生物制药

办公电话:87836176

电子邮件:haolinlin@jlu.edu.cn

学习与工作经历:

1.受教育经历

1999.09-2003.06,吉林农业大学动物科学农学学士

2003.09-2006.06,吉林大学生物化学与分子生物学理学硕士

2006.09-2009.06,吉林大学生物化学与分子生物学理学博士

2008.10-2009.10,科隆大学生物化学所访问学者

2.工作经历

2009.07-2011.09,吉林大学畜牧兽医学院生物技术系讲师

2011.09-2016.09,吉林大学动物科学学院副教授硕士研究生导师

2016.09-至今,吉林大学动物科学学院教授

2017.09-至今,吉林大学动物科学学院教授博士研究生导师

主要教学工作(承担的本科生、研究生课程)

本科生课程:动物生物化学、动物生物化学实验技术、生物化学实验技术、

硕士生课程:高级动物生物化学、生物工程下游技术

主要科研工作(包括科研项目)

1.小型猪IGF-1基因变异在发育性骨生长中的作用及机制(31672514)国家自然科学基金2017.01-2020.1263万元主持人在研

2.小型猪胰岛素样生长因子-1基因变异对其功能(20170101024JC)吉林省科技发展计划项目2017.01-2019.1213万元主持人在研

3.以动物蛋白质为抗原的单克隆抗体制备横向课题2017.01-2018.1225万元主持人在研

4.特种长白山动物资源肽高值开发集成与产品横向课题2017.06-2018.062万元主持人在研

5.一款含有林蛙皮多肽的宠物零食研制横向课题2016.07-2017.036万元主持人在研

6.十款含有林蛙皮多肽的化妆品技术开发横向课题2016.03-2016.12 23万元主持人在研

7.促进创伤愈合的林蛙皮复合多肽提取工艺的建立及应用长春市科技局支撑计划科研项目2013.12-2015.1230万元主持人完成

8.小型猪中IGF-1及其受体表达特征及作用机制的研究(31101781)国家自然科学基金2012.01-2014.12 23万元主持人完成

科研成果(著作、专利、论文)

1.著作

(1)2011高级生物化学实验技术科学出版社主编教材

(2)2014现代动物病毒学中国农业出版社参编教材

(3)2015分子生物学实验原理与技术科学出版社参编教材

2.专利

(1)一种基因治疗用载体蛋白及其制备方法和用途 CN 104031134 B2015.07

(2)一种用于皮肤美容保健的复合鹿茸多肽冻干粉与纳米级缓冲微乳组合精华素及其制备方法,201310033710.X,20130129

(3)一种用于海洋生物多肽提取液的快速浓缩装置201320428630.X2013-07-17

(4)种好氧反硝化耐冷菌及制备方法102337232B

(5)添加林蛙皮肤混合多肽功能芯片的卫生巾 202875614U

3.论文

SCI论文

[1]2018 Linkage disequilibrium and functional analysis of PRE1 insertion together with SNPs in the promoter region of IGFBP7 gene in different pig breeds. J Appl Genet. 2018. 59(2):231-241通许作者 1.756

[2] 2018 The mechanism of dietary protein modulation of bone metabolism via aterations in members of the GH/IGF axis. Curr Protein Pept Sci. Online通讯作者 2.696

[3] 2018 Porcine IGF1 synonymous mutation alter gene expression and protein binding affinity with IGF1R. International Journal of Biological Macromolecules. 116 (2018) 23-30.通迅作者 3.909

[4] 2017 Effects of GnRHR polymorphisms on sperm quality in Chinese water buffalo. Animal Reproduction Science. 2017 Nov;186:37-43并列第一作者,一作为学生 1.647

[5] 2017 Identification of Four SNPs in LHB Gene and Their Associations with Sperm Qualities of Chinese Buffaloes. Animal Biotechnology, 2017, 7.3. 28(3):168-173.通讯作者 0.928

[6] 2017 Novel short antimicrobial peptide isolated from Xenopus laevis skin. Journal Peptide Science. 2017, 5.23. 23(5): 403-409.通讯作者 1.969

[7] 2017 Polypeptides from the skin of Rana Chensinensis Exert the Antioxidant and Antiapoptotic Activities on HaCaT cells, Animal Biotechnology, 2017, 1.2; 28(1):1-10.通讯作者 0.928

[8] 2016 The association of haplotypes in IGFBP-3 gene promoter region and tissue expressions in three pig breeds. Animal cells and systems, 2016, 12.30 20(6): 384-393.通讯作者 0.376

[9] 2016 The effect of heat stress on bull sperm quality and related HSPs expression, Animal Biology, 2016, 12.1 66(3-4): 321-333.通讯作者 0.574

[10] 2016 Electrospun poly(l-lactide)/zein nanofiber mats loaded with Rana chensinensis skin peptides for wound dressing, Journal of Materials Science, 2016, 9.1 27:136.通讯作者 2.599

[11] 2016 Missense mutations in the signal peptide of the porcine GH gene affect cellular synthesis and secretion, Pituitary, 2016, 19(4):362-369.通讯作者2.481

[12] 2016 Expression Profiles of IGF-1R Gene and Polymorphisms of its Regulatory Regions in Different Pig Breeds, Protein J, 2016, 6.1 35(2016):231-236.通讯作者 1.139

[13] 2016 A novel short anionic antimicrobial peptide isolated from the skin of Xenopus laevis with broad antimicrobial activity and inhibitory activity against Breast cancer cell,Archives of Microbiology,2016, 3.并列第一作者,一作为学生1.6

[14] 2016 CspE is overproduced by temperature downshift in the Acinetobacter johnsonii DBP-3,Current Microbiology,2016.并列第一作者,一作为学生1.322

[15] 2016 Distribution and linkage disequilibrium analysis of polymorphisms of GH1 gene in different populations of pigs, associated with body size,Journal of genetics,2016,95(1):79-87.通讯作者 0.995

[16] 2016 Highly Efficient and Rapid Detection of the Cleavage Activity of Cas9/gRNA via a Fluorescent Reporter, Appl Biochem Biotechnol, 2016, 10.1 180(4):655-667.并列第一作者,一作为学生 1.751

[17] 2015 Linkage analysis of SNPs in IGFBP-6 and its relation with the body sizes of pig,Genetics and Molecular Research,2015,14(4): 17273-17280.通讯作者 0.764

[18] 2015 SNPs in the 5’ terminal-region of IGFBP6 gene and its linkage with pig body size,Animal Cells and Systems,2015,19(6): 417-424.通讯作者 0.481

[19]2015 Prokaryotic-expressed porcine IFN a1-THY a 1 fusion proteins exert IFN and THY activities in vitro,Biologicals,2015,43(2015): 225-231.通讯作者 1.69

[20] 2014 Vascular endothelial growth factor expression correlated with microvessel density in the antral follicle of sheep ovary,Livestock Science,2014,165(3):212-216.第一作者 1,171

[21] 2014 Controlled Delivery of Growth-Hormone-Releasing Peptide 6 from the Poly(lactic-co-glycolic acid)–Poly(ethylene glycol)–Poly(lactic-co-glycolic acid) Copolymer and the Effect of a Growth-Hormone-Releasing Peptide 6–Copolymer Hydrogel on the Growth of,APPL. POLYM. SCI,2014,131(9): 1-8.通讯作者 1.768

[22] 2014 Polymorphism analysis of IGFBP-5 gene exon 1 in Tibet Mini-pig and Junmu No. 1 White pig,Genetics and Molecular Research,2014,13(1):1643-1649.通讯作者 0.775

[23] 2013 The characteristics of nitrate removal by the psychrotolerant denitrifying bacterium Acinetobacter johnonii DBP-3, isolated from a low-temperature eutrophic body of water,Journal of Environmental Science and Health - Part B: Pesticides, Food Contaminants, and Agricultural Wastes,2013,48(10):885-892.通讯作者1.211

[24] 2013 Isolation of nitrobenzene degrading strain Pseudomonas NB001 and application in the bioremediation of polluted water body,Journal of Environmental Science and Health - Part A: Toxic/Hazardous Substances & Environmental Engineering,2012,47(1): 70-76.通讯作者 1.135

[25] 2012 The combination of a synthetic promoter and a CMV promoter improves foreign gene expression efficiency in myocytes,Journal of Biotechnology,2012,158(3): 91-96.2.884

[26] 2011 Function identification of bovine Nramp1 promoter and intron1,Animal Cells and Systems,2011,15(3)227-233.第一作者 0.122

[27] 2011 Growth hormone and receptor gene mutations in Chinese Banna miniature pig,Animal Cells and Systems,2011,15(4):310-314.并列第一作者,一作为学生 0.122

[28] 2011 Single nucleotide polymorphism analysis of exons 3 and 4 of IGF-1 gene in pigs,Genetics and Molecular Research, 2011, 10(3): 1689-1695.第一作者 1.013

[29] 2010 Reduced Somatostatin in Hypothalamus of Young Male Mouse Increases Local but not Circulatory GH,Neurochemical Research,2010,35(1):143-151.第一作者 2.608

[30] 2010 Effects of a mild heat treatment on mouse testicular gene expression and sperm quality,Animal Cells and Systems,2010,14(4):267-274.通讯作者 0.415

中文核心:

1.慢病毒介导的小鼠生长抑素shRNA序列的设计和筛选,中国兽医学报,2011,(01):65-69.第一作者

2.关于动物生物化学双语教学的几点思考,长春大学学报,2011,(08):116-117.第一作者

3.睾丸酮丛毛单胞菌PhaR基因敲除菌株的构建及其3,17β-HSD对甾族化合物的响应特性,环境科学学报,2014,(11):2773-2778.通讯作者

4.不同品种猪IGFBP-3启动子区突变位点筛查及分析,中国兽医学报,2014,34(11):1800-1804.第八作者

5.猪IGF-1及其受体基因部分组织表达规律的研究,中国兽医学报,2013,(10):1568-1572.第二作者

6. 4个猪种IGF-1基因核心启动子区的克隆及生物信息学分析,吉林农业大学学报,2013,35(5):587-590.第四作者

7.小鼠IGFBP-6基因shRNA的设计与筛选,中国兽医学报,2013,33(4):586-591.第三作者

8.西藏小型猪与军牧一号白猪IGFBP-6基因表达差异分析,吉林农业大学学报,2013,(06):727-731.第五作者

9. GHRP-6温敏型凝胶的制备及其对小鼠生长的影响,中国兽医学报,2013,(12):1879-1884.第五作者

10.部分小型猪与大型猪IGF-1基因的SNP分析,中国兽医学报,2011,(05):750-753+758.第三作者

11.热应激对西门塔尔牛精液品质及顶体反应相关酶活力的影响,内蒙古农业大学学报(自然科学版),2011,(01):13-16.第二作者

12.热应激条件对雄性小鼠精液顶体反应相关酶活力的影响,中国兽医学报,2011,(05):740-742+749.第二作者

13. PBL教学模式在生物化学实验课教学中的尝试,长春师范学院学报,2011,(02):111-112.第二作者

六 奖励与荣誉

1.2014吉林省自然科学学术成果奖二等奖吉林省科学技术协会2014

2.2013吉林省自然科学学术成果奖二等奖吉林省科学技术协会2013

3.第十四届东南亚地区医学美容学术大会“优秀中医美容奖”

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